Catecholamine Depletion in Thyrotoxicosis. Effect of Guanethidine on Cardiovascular Dynamics.
نویسندگان
چکیده
منابع مشابه
Analysis of the acute circulatory effects of guanethidine and bretylium.
• Guanethidine and bretylium are two relatively new drugs used in the treatment of hypertension. Both of these agents may produce a triphasic effect on arterial pressure when administered intravenously; the initial response is usually an abrupt fall in arterial pressure lasting less than 5 minutes, followed by a more sustained pressor effect which may persist for 30 minutes to 2 hours, dependin...
متن کاملEffect of guanethidine and bretylium on the dog heart-lung preparation.
GUAXETHIDINE and bretylium are reported to produce hypotension by interference with transmission at the adrenergic neuro-effector junction and to have S3mpathomimetic effects after intravenous injection in dogs and cats.' 2 In the case of guanethidine, Maxwell et al. have suggested that these effects are due to initial catecholamine release. Recently, Cass et al. have shown that guanethidine de...
متن کاملBeta-adrenergic blockade in the management of acute thyrotoxic crisis, tachycardia and arrhythmias.
TACHYCARDIA is a characteristic feature of thyrotoxicosis at all ages, but the older the patient the more frequent the occurrence of atrial fibrillation. Treatment of thyrotoxicosis is followed by slowing of heart rate and more than half of the thyrotoxic patients with atrial fibrillation, who are treated with anti-thyroid drugs or surgery (Sandler & Wilson, 1959) or radioactive iodine therapy ...
متن کاملEffect of Guanethidine and Bretylium on the Dog Heart-Lung Preparation
GUAXETHIDINE and bretylium are reported to produce hypotension by interference with transmission at the adrenergic neuro-effector junction and to have S3mpathomimetic effects after intravenous injection in dogs and cats.' 2 In the case of guanethidine, Maxwell et al. have suggested that these effects are due to initial catecholamine release. Recently, Cass et al. have shown that guanethidine de...
متن کاملSympathetic control of aqueous secretion in man.
The use of adrenaline in the treatment ofopen-angle glaucoma has both clinical acceptance and experimental support. But the mechanism underlying its ocular hypotensive action is still poorly understood. The role of the sympathetic nervous system in the regulation of aqueous dynamics is also not clearly worked out for man, though our understanding has been greatly increased in recent years. It i...
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عنوان ژورنال:
- Circulation
دوره 31 شماره
صفحات -
تاریخ انتشار 1965